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Robert Layfield Selected Research

Pathological Protein Aggregation

1/2005The ubiquitin-proteasome system and neurodegenerative disorders.

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Robert Layfield Research Topics

Disease

11Osteitis Deformans (Paget's Disease of Bone)
07/2014 - 09/2003
9Neurodegenerative Diseases (Neurodegenerative Disease)
10/2016 - 10/2002
5Neoplasms (Cancer)
01/2019 - 03/2007
5Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
01/2015 - 10/2009
4Parkinson Disease (Parkinson's Disease)
09/2009 - 10/2003
3Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
10/2016 - 05/2015
2Bone Resorption
08/2013 - 11/2007
2Breast Neoplasms (Breast Cancer)
05/2009 - 06/2007
1Osteosarcoma (Osteogenic Sarcoma)
01/2019
1Pain (Aches)
01/2019
1Osteoporosis
01/2019
1Glioblastoma (Glioblastoma Multiforme)
01/2017
1Glioma (Gliomas)
01/2017
1Pre-Eclampsia (Preeclampsia)
01/2015
1Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
05/2014
1Endometrial Neoplasms (Endometrial Cancer)
07/2013
1Ovarian Neoplasms (Ovarian Cancer)
12/2012
1Carcinoma (Carcinomatosis)
12/2012
1Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy)
03/2010
1Epileptic Syndromes
03/2010
1Thrombosis (Thrombus)
10/2009
1Cardiomegaly (Heart Hypertrophy)
06/2009
1Neuroblastoma
04/2008
1Mitochondrial Diseases (Mitochondrial Disease)
08/2007
1Muscular Atrophy (Muscle Atrophy)
08/2007
1Atrophy
08/2007
1Necrosis
03/2007
1Lung Neoplasms (Lung Cancer)
03/2007
1Cicatrix (Scar)
05/2005
1Pathological Protein Aggregation
01/2005
1Familial Paget's disease of bone
07/2004
1Alzheimer Disease (Alzheimer's Disease)
10/2003

Drug/Important Bio-Agent (IBA)

16Proteins (Proteins, Gene)FDA Link
01/2017 - 10/2003
16UbiquitinIBA
07/2014 - 09/2003
6Biomarkers (Surrogate Marker)IBA
01/2015 - 06/2007
5Proteasome Endopeptidase Complex (Proteasome)IBA
08/2008 - 10/2003
4NF-kappa B (NF-kB)IBA
02/2010 - 11/2007
3Protein AggregatesIBA
06/2008 - 10/2003
2AntioxidantsIBA
10/2016 - 10/2009
2LipidsIBA
01/2016 - 08/2007
1MineralsIBA
01/2019
1Zoledronic Acid (Zometa)FDA Link
01/2019
1MicroRNAs (MicroRNA)IBA
01/2019
1Diphosphonates (Bisphosphonates)IBA
01/2019
1Histones (Histone)IBA
01/2017
1dipinacoline glutamateIBA
01/2017
1AntibodiesIBA
01/2017
1Transcription Factors (Transcription Factor)IBA
10/2016
1Peptide Hydrolases (Proteases)FDA Link
05/2014
1Serine Proteases (Serine Protease)IBA
05/2014
1Mutant Proteins (Protein, Mutant)IBA
08/2013
1Cystatin BIBA
03/2010
1PolyubiquitinIBA
09/2009
1Ventricular MyosinsIBA
06/2009
1AnnexinsIBA
05/2009
1Dopamine (Intropin)FDA LinkGeneric
04/2008
1Glutathione (Reduced Glutathione)IBA
04/2008
1Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA
02/2008
1GW 610742IBA
08/2007
1CarbohydratesIBA
08/2007
1PPAR deltaIBA
08/2007
1Doxorubicin (Adriamycin)FDA LinkGeneric
06/2007
1Paclitaxel (Taxol)FDA LinkGeneric
06/2007
1capsazepineIBA
03/2007
1Capsaicin (Zostrix)FDA Link
03/2007
1LigandsIBA
03/2007
1resiniferatoxinIBA
03/2007
1N- (3- methoxyphenyl)- 4- chlorocinnamanilideIBA
03/2007
1alpha-SynucleinIBA
10/2003
1EnzymesIBA
10/2003
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
10/2002

Therapy/Procedure

1Neoadjuvant Therapy
05/2009
1Drug Therapy (Chemotherapy)
06/2007